Research Areas

image

Bioimaging

(Cai, Gharib, Lester, Meyerowitz, Pierce, Shapiro, Yang)
Biophotonics, advanced imaging technologies, computational image analysis, noninvasive biomedical imaging, single-molecule technologies, flow-field imaging technologies, in situ amplification.

image

Bioinspired Design

(Dickinson, Gharib, Greer, Hajimiri, Ismagilov, Murray, Shapiro, Tirrell, Winfree)
Engineering physiological machines, engineering self-powered technologies, control systems, synthetic heteropolymers, and self-healing circuits and systems.

Biomechanics

(Bhattacharya, Dickinson, Gharib, Greer, Meyerowitz, Phillips, Roukes)
Molecular and cellular biophysics, cardiovascular mechanics, muscle and membrane mechanics, physiology and mechanics of flapping flight, multicellular morphodynamics, cell-biomaterial interactions.

image

Biomedical Devices

(Burdick, Emami, Gharib, Hajimiri, Heath, Ismagilov, Meister, Roukes, Shapiro, Siapas, Tai, Yang)
BioNEMS, BioMEMS, laboratories-on-a-chip including microfluidic systems, neural networks, microscopes, and diagnostics, novel measurement principles, neural interfaces and prostheses, locomotion rehabilitation, molecular imaging during surgery.

image

Cell and Tissue Engineering

(Arnold, Elowitz, Gharib, Gradinaru, Ismagilov, Shapiro, Tirrell)
Multicellular morphodynamics, principles of feedback between tissue mechanics and genetic expression, non-natural protein biomaterials, cell-biomaterial interactions, developmental patterning.

image

Molecular Medicine

(Baltimore, Bjorkman, Davis, Deshaies, Gradinaru, Hay, Ismagilov, Lester, Mazmanian, Pierce)
Engineering immunity, cancer vaccines, AIDS vaccine, novel anti-cancer therapeutics, Parkinson’s disease, schizophrenia, Huntington's disease, nicotine addiction, microbiome perturbations in disease, molecular basis of autism, programmable chemotherapies, conditional chemotherapies, nanoparticle drug delivery.

image

Molecular Programming

(Aravin, Murray, Pierce, Qian, Rothemund, Winfree)
Abstractions, languages, algorithms and compilers for programming nucleic acid function, molecular information processing, molecular complexity theory, free energy landscapes, metastable systems, self-assembly across length scales, algorithmic self-assembly, synthetic molecular motors, in vitro and in vivo nucleic acid circuits.

image

Synthetic Biology

(Aravin, Arnold, Elowitz, Gradinaru, Ismagilov, Murray, Pierce, Qian, Rothemund, Shapiro, Tirrell, Winfree)
Principles of biological circuit design, genetic circuits, protein engineering, noncanonical amino acids, nucleic acid engineering, rational design, directed evolution, metabolic engineering, biofuels, biocatalysts, elucidation of systems biology principles using synthetic systems.

image

Systems Biology

(Aravin, Cai, Doyle, Elowitz, Goentoro, Heath, Ismagilov, Lester, Meister, Meyerowitz, Murray, Phillips, Sternberg, Winfree)
Roles of circuit architecture and stochasticity in cellular decision making, feedback, control and complexity in biological networks, multicellular morphodynamics, principles of developmental circuitry including signal integration and coordination, spatial patterning, and organ formation, principles of feedback between tissue mechanics and genetic expression, neural development and disease.